Get the facts on Oral Submucous Fibrosis treatment, diagnosis, staging, causes, types, symptoms. Information and current news about clinical trials and trial-related data, Oral Submucous Fibrosis prevention, screening, research, statistics and other Oral Submucous Fibrosis related topics. We answer all your qestions about Oral Submucous Fibrosis.
Question: What is treatment for Oral SubMucous Fibrosis? Besides stopping gutka consumption
Answer: OSF caused by consumption of pan or gutka, can be cured by using anti oxident drugs, along with stopping of causative agents.anti oxidents availabla in markets are `ala 100` and `softace` these can be consumed twice daily, for a month or more..
Question: Hi,Can anyone tell me about possible treatment options of oral submucous fibrosis...? Specially interferon gamma and steroids.....
I hve read an artical saying interferon gamma can reverse it.....
Answer: Drug Name
Dexamethasone (Decadron) -- For various inflammatory diseases. Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability.
Adult Dose 4 mg IV/IM (suggested in studies)
Pediatric Dose Dose in children should be based on severity of disease and response rather than adherence to dose indicated by age, body weight, or BSA
Contraindications Documented hypersensitivity; active bacterial or fungal infection
Interactions Effects decrease with coadministration of barbiturates, phenytoin, and rifampin; decreases effect of salicylates and vaccines used for immunization
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Increases risk of multiple complications, including severe infections; monitor adrenal insufficiency when tapering drug; abrupt discontinuation of glucocorticoids may cause adrenal crisis; hyperglycemia, edema, osteonecrosis, myopathy, peptic ulcer disease, hypokalemia, osteoporosis, euphoria, psychosis, myasthenia gravis, growth suppression, and infections are possible complications; caution with individuals exposed to viral illnesses, such as chickenpox or measles
Drug Name
Triamcinolone acetonide (Aristocort, Kenaject) -- Suppresses immune system by reducing activity and volume of lymphatic system. Treats inflammatory mucosal lesions that are responsive to steroids. Decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and by reversing capillary permeability.
Adult Dose Oral inflammatory or ulcerative lesions (dental paste): Apply thin film bid/tid pc and hs
40-80 mg IM (studies have used 10 mg/mL diluted in 1 mL of lidocaine 2% to avoid tissue irritation and facilitate proper distribution of drug)
Pediatric Dose Not established
Contraindications Documented hypersensitivity; fungal, viral, and mycobacterial mucosal infections
Interactions Coadministration with barbiturates, phenytoin, and rifampin decreases effects; effects of vaccine and toxoid may be reduced
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Multiple complications (eg, severe infections, hyperglycemia, edema, osteonecrosis, myopathy, peptic ulcer disease, hypokalemia, osteoporosis, euphoria, psychosis, myasthenia gravis, growth suppression) may occur; abrupt discontinuation may cause adrenal crisis
Drug Name
Betamethasone valerate (Diprosone) -- For inflammatory reactions responsive to steroids. Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and by reversing capillary permeability. Affects production of lymphokines and has inhibitory effect on Langerhans cells.
Adult Dose Suggested dose: 0.05% topically q6h for 3 wk
Pediatric Dose Not established
Contraindications Documented hypersensitivity; paronychia; cellulitis; impetigo; angular cheilitis; erythrasma; erysipelas; rosacea; perioral dermatitis; acne
Interactions None reported
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Do not use in skin with decreased circulation; can cause atrophy of groin, face, and axillae; may cause striae distensae and rosacealike eruption; may increase skin fragility; rarely may suppress HPA axis; if infection develops and is not responsive to antibiotic treatment, discontinue until infection is under control; do not use monotherapy to treat widespread plaque psoriasis
Drug Category: Extravasation antidotes -- Can enhance the diffusion of locally irritating or toxic drugs in the management of intravenous extravasation.Drug Name
Hyaluronidase (Wydase Injection) -- Stimulates hydrolysis of hyaluronic acid, one of the chief ingredients of tissue cement, which offers resistance to diffusion of liquids through tissues. Used to aid in absorption and dispersion of injected drugs.
Adult Dose 150 U added to vehicle solution and administered SC/ID
Pediatric Dose Administer as in adults
Contraindications Documented hypersensitivity
Interactions Salicylates, cortisone, corticotropin, estrogens, and antihistamines may decrease effects
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Avoid injecting into inflamed or cancerous areas; perform intradermal skin test for sensitivity before initiating infusion; discontinue if sensitivity or extravasation occur
Drug Category: Interferons -- Are naturally produced proteins with antiviral, antitumor and immunomodulatory actions. Alpha-, beta-, and gamma-interferons may be given topically, systemically, or intralesionally.Drug Name
Interferon gamma (Actimmune) -- Believed to act via ability to counteract cell surface expression of proinflammatory or proadhesion molecules on immune cells, among other effects. More studies needed to fully understand mechanisms of action.
Adult Dose BSA >0.5 m2: 50 mcg/m2 SC 3 times/wk
BSA <0.5 m2: 1.5 mcg/kg/dose SC 3 times/wk
Pediatric Dose Not established
Contraindications Documented hypersensitivity; Escherichia coli derivatives or components
Interactions Live vaccines; rotavirus vaccine
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Caution in preexisting cardiac disease, seizure disorder, or compromised CNS function; myelosuppression
Question: i want to know the medicine for oral submucous fibrosis , also any good medicine for mouth opening problem ? i m from india so if any aryuvedic medicine or other available in india
Answer: I'm pretty sure there is no treatment for it. I believe it is caused by certain types of smokeless tobacco. Plastic surgeons can sometimes surgically repair the opening of the mouth.
