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Multiple Endocrine Neoplasia Type 1

Get the facts on Multiple Endocrine Neoplasia Type 1 treatment, diagnosis, staging, causes, types, symptoms. Information and current news about clinical trials and trial-related data, Multiple Endocrine Neoplasia Type 1 prevention, screening, research, statistics and other Multiple Endocrine Neoplasia Type 1 related topics. We answer all your qestions about Multiple Endocrine Neoplasia Type 1.

Question: What are the symptoms of Pancreatic tumors in Multiple Endocrine Neoplasia, Type 1? Hi :), Is there anyone out there in YA who has MEN, Type 1, or a doctor that can give me some involved information? My question is about Wermer's Syndrome, or Multiple Endocrine Neoplasia Type 1. I have had two doctors tell me that I definitely have it; two tell me that I don't have it; and one tell me that he doesn't know. I have a pituitary microprolactinoma, and have had a parathyroidectomy, but if there are pancreatic tumors, they have not yet shown up on scans. I was told that I don't have MEN, type1 because of this. I have also been told that I do have it because I have all the symptoms of pancreatic tumors. The doctor said that tumors are probably microscopic and haven't shown up yet, and its better that way. The slower they grow, the better off I will be. What are the symptoms that I can look for? I cannot afford DNA testing, and my insurance won't pay for it. I need to know some symptoms that can be readily seen in my everyday life. I forgot to mention- during the parathyroidectomy, three 1/2 of the four parathyroid gland were removed. They were not malignant, but they all had tumors/growths- whatever it is that people with MEN have.

Answer: In MEN1, all four parathyroid glands tend to be overactive. They release too much parathyroid hormone, leading to excess calcium in the blood. High blood calcium, known as hypercalcemia, can exist for many years before it is found by accident or by family screening. Unrecognized hypercalcemia can cause excess calcium to spill into the urine, leading to kidney stones or kidney damage. Nearly everyone who inherits a susceptibility to MEN1 (a "cancer") will develop overactive parathyroid glands (hyperparathyroidism) by age 50, but the disorder can often be detected before age 20. Hyperparathyroidism may cause no problems for many years or it may cause problems such as tiredness, weakness, muscle or bone pain, constipation, indigestion, kidney stones, or thinning of bones. Rare EFFECTS: and I stress RARE! Occasionally, a person who has MEN1 develops an islet tumor of the pancreas which secretes high levels of pancreatic hormones other than gastrin. Insulinomas, for example, produce too much insulin, causing serious low blood sugar, or hypoglycemia. Pancreatic tumors that secrete too much glucagon or somatostatin can cause diabetes, and too much vasoactive intestinal peptide can cause watery diarrhea. Other rare complications arise from pituitary tumors that release high amounts of ACTH, which in turn stimulates the adrenal glands to produce excess cortisol. Pituitary tumors that produce growth hormone cause excessive bone growth or disfigurement. Another rare complication is an endocrine tumor inside the chest or in the stomach, known as a carcinoid. In a person with MEN1 a carcinoid tumor rarely secretes a hormone. In general, surgery is the mainstay of treatment for all of these rare types of tumors, except for gastric carcinoids which usually require no treatment.

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