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Varicella Zoster

Get the facts on Varicella Zoster treatment, diagnosis, staging, causes, types, symptoms. Information and current news about clinical trials and trial-related data, Varicella Zoster prevention, screening, research, statistics and other Varicella Zoster related topics. We answer all your qestions about Varicella Zoster.

Question: How does the Varicella-zoster virus interact with the body to cause the symptoms of chickenpox?

Answer: What you're asking is what is the pathophysiology of the disease, right? The virus enters the respiratory tract and quickly replicates. VZV is an enveloped, double-stranded DNA virus. It attaches to the wall of the cell it invades and then enters the cell. The virus uncoats and is transported to the nucleus where the viral DNA replicates creating new virions that are eventually released from the cell to infect other cells. Since there's gas exchange in the respiratory tract, the virus is certainly small enough to enter the blood and then is carried through the bloodstream to the skin where it causes a rash. While the virus is in the bloodstream (before the rash begins) it causes typical viral symptoms like fever, fatigue, joint pains, headache, and swollen glands. These are immune responses. Kinda fundamental. Are you asking this because you have homework to finish?

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