Chronic Granulomatous Disease

Question: Chronic Granulomatous Disease? 27/ F Last year I had a skin infection under my breasts. ( they looked sort of like boils)I went to the doctor and he perscribed numerous different topical and oral antiobiotics which didn't clear it up. He then sent me to a dermatologist who did a culture. It came back as Proteus Mirabilis bacteria which they said was rare. I went to an ifectious disease doctor who did bloodwork and diagnosed me w/Chronic Granulomatous Disease. He hospitalized me and put me on I/V antibiotics. It cleared up. One week later it came back. I went back in the hospital for a week and came home with a pic line to cont. for 6 weeks with i/v antiobiotics. Finally it cleared up for a month. I asked him to test me again for CGD disease and this time it came back negative. A year and a half later the infection is back again. I have had a low grade fever for the past year and a half, have "hot flashes, low energy and a general feeling of being sick. No one seems to know what is going on. How can I improve?

Answer: Chronic granulomatous disease is usually a serious disease and is generally diagnosed in childhood. It's genetic and is inherited in one of two ways - X-linked (only affects men; women can be carriers and there are some reports of a 'carrier syndrome') and autosomal recessive. It is a disorder of neutrophil function and means that you often get frequent and severe bacterial and fungal infections. There are different diagnostic tests. The traditional test for CGD is the Nitrablue Tetrazolium test which is cheap and efficient but does not tell you what inheritance pattern you have (because it just looks at your neutrophil function). Genetic testing is possible but you would need to be tested along with close family members as there is not one single mutation but many (and it's more efficient to test for the one that runs in your family). If you are still unwell, request a repeat test and a referral to either an Immunologist or a Geneticist. Even though your history does not sound typical, it is still possible that you have the diagnosis and it is important for your prognosis (not to mention family planning) that you know where you stand. BUT Your fever and rash need to be adequately treated regardless of your CGD status. They are significant symptoms and if you might require IV antibiotics, you might as well treat it promptly.

Question: A chronic granulomatous disease. Is it possible for a child to grow out of it, later on.?

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