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Neutropenia

Get the facts on Neutropenia treatment, diagnosis, staging, causes, types, symptoms. Information and current news about clinical trials and trial-related data, Neutropenia prevention, screening, research, statistics and other Neutropenia related topics. We answer all your qestions about Neutropenia.

Question: Neutropenia? I recently found out that I have Neutropenia in my blood. I was wondering if anyone out there has had or know someone that has had to experience this. I'm about to have a bone marrow sample treatment or whatever, but I'm really wanting to know what to expect, types of treatments given and the severity of this. PLEASE HELP! Any information would be helpful!

Answer: Neutropenia isn't IN your blood. It's a term characterizing your blood cells, or in this case, lack there of. Blood consists of red blood cells, white blood cells, and platelets. Neutropenia is the absence of a certain type of white blood cell, the neutrophil. (Neutro- neutrophil; penia-low/deficiency). White blood cells play a huge role in the body's defense against bacteria and viruses. The neutrophil pretty much "eats" those bad organisms that invade your body. Now, your bones are hollow and inside of the bone is what is called the marrow. That's where blood cells grow. If they want a bone marrow sample, they're probably looking to confirm the low count. (My sister has TTP (another rare blood condition) and had to have a bone marrow aspirate/sample. They lie you on your side and use local anesthetic to numb the skin and muscles. They take a very long needle and insert it though the lower back/hip area and into the bone, extracting the marrow through the syringe. You're going to feel pressure when it enters the bone and slight pain when they aspirate the marrow. It doesn't last more than 5 minutes and the pain only occurs when they remove the bone marrow. They may sedate you if you're younger.) Now, I've never known anyone with neutropenia but I can tell you that this isn't a very dangerous condition IF TREATED. Luckily for you, and a lot of other people, medicine has come a really long way and there is some form of treatment for just about anything. Now, because your body is low on neutrophils, your body will have a more difficult time fighting off infection, so one of the treatments could be antibiotics. They also have medications that will help your bone marrow produce more neutrophils. ANOTHER form of treatment is a bone marrow transplant. A doctor would probably only consider this if the patient (you) weren't responding well to the other treatments or any other number of reasons. In this case, they would take a blood sample and compare it first to any family members who would want to donate marrow for you to use. If your blood types matched (along with other factors) they would take bone marrow samples from each of you and make sure they match completely (there are a lot of complicating things when it comes to blood that have to be matched almost perfectly or the person receiving it could have a bad reaction). If they match, the transplant would take place. When it comes to the transplant itself, I can't tell you as most of my knowledge really pertains to the blood/cellular aspect. Whenever you have an appointment, you need to ask your doctor as much as you can, ok? If you have a lot of questions, ask them. They're there to answer any and all questions you have. After all, you may have to live with this for the rest of your life. Just make sure you know what your doctor is going to be doing. And if you don't understand what he's saying, tell him to explain it simply. If you have any more questions, you can always email me, but it's always best that you talk to your doctor.


Neutropenia News

STAT3 Mutations Linked to Rare Leukemia

MedPage Today
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U.S. News & World Report

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African Business Review (press release)
 

Excessive neutropenia for weekly wverolimus + docetaxel

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Clinical Oncology News

First cycle G-CSF for high-risk chemotherapy: Of Course!
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Millennium and Seattle Genetics Initiate Global Phase 3 Trial of ADCETRIS(TM ...

MarketWatch (press release)
Neutropenia: Monitor complete blood counts prior to each dose of ADCETRIS and consider more frequent monitoring for patients with Grade 3 or 4 neutropenia. If Grade 3 or 4 neutropenia develops, manage by dose delays, reductions or discontinuation.
 

Cellerant Announces Publication Demonstrating Significant Survival Benefits ...

MarketWatch (press release)
Cellerant is developing CLT-008 as an effective treatment for chemotherapy-induced neutropenia, protection following exposure to acute radiation, and facilitating engraftment of cord blood transplantation. CLT-008 is currently in a Phase 1 study in ...
 

Mother's Day Wish -- First Lady Obama, Please Help Save The Life of 9-year-old ...

MarketWatch (press release)
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New Study Shows Patients Can Effectively be Switched to Latuda(R) (lurasidone ...

MarketWatch (press release)
Leukopenia, Neutropenia, and Agranulocytosis: Leukopenia/neutropenia has been reported during treatment with antipsychotic agents. Agranulocytosis (including fatal cases) has been reported with other agents in the class. Patients with a preexisting low ...
 

Latuda(R) (lurasidone HCl) Label Updated With Expanded Dosing Range Providing ...

MarketWatch (press release)
Leukopenia, Neutropenia, and Agranulocytosis: Leukopenia/neutropenia has been reported during treatment with antipsychotic agents. Agranulocytosis (including fatal cases) has been reported with other agents in the class. Patients with a preexisting low ...
 

Targeted Therapies in the Management of Leukemia and Lymphoma

Cancer Network
It is increased in frequency when rituximab is combined with chemotherapy; however, a higher rate of neutropenia is not noted when rituximab is combined with chemotherapy. Lymphocyte depletion occurs in 70% to 80% of patients, and may be responsible ...