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Question: Molecular Biology question I don't have an answer for? Which of the following mechanisms would NOT explain the decrease in beta-pancreatic cells in Diabetes Mellitus Type I patients?
a) Absence of beta-pancreatic stem cells.
b) Necrosis due to free radicals produced by macrophages
c) Lysis due to water intake through perforins secreted by CD8+ T cells.
d) Apoptosis due to cytochrome c release because of a change in membrane potential of the mytochrondia in beta-pancreatic cells
e) Apoptosis by activation of the intrinsic path by union of Fas in CD4+ T cells and Fas ligand in beta-pancreatic cells...
I've got an idea of which might be but I'm really not sure.
Answer: As a guess I'd say "e" because I haven't heard of FasL/FasR being involved in pancreatic cell death.
