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Basal Cell Carcinoma

Get the facts on Basal Cell Carcinoma treatment, diagnosis, staging, causes, types, symptoms. Information and current news about clinical trials and trial-related data, Basal Cell Carcinoma prevention, screening, research, statistics and other Basal Cell Carcinoma related topics. We answer all your qestions about Basal Cell Carcinoma.

Question: Can I have a basal cell carcinoma on my foot? Has this happened to anyone, what I thought was a wart is infact a basal cell carcinoma. How was it treated if this happened to you. Thanks.

Answer: Skin cancer is a major problem in the elderly. Squamous cell carcinoma (SCC), the second most common skin cancer, typically occurs in this age group. Despite a number of modalities readily available for treatment. Consequently, the search for novel treatments continues. To my knowledge, there are only 6 published reports of invasive SCC treated with 5-percent Imiquimod cream. (Imiquimod is a topically applied imidazoquiline immunomodulator that enhances both innate and cell-mediated immunity ) This is a clinical trial result that has details that may be of interest:- An 89-year-old woman presented with three lesions on her lower limbs. She had previous treatments for multiple basal cell carcinomas, actinic keratoses, Bowen disease, and invasive SCCs at various sites. The new lesions were on the left foot (one) and right lower leg (two) and all showed changes of poorly differentiated SCC histologically. She declined surgical excision; radiotherapy was felt to be a poor option. She was treated with 5-percent imiquimod cream, initially to just the lesion on the dorsum of the foot, for 8-12 hours at night for three nights each week (three times a week). Treatment was well tolerated by week 2, so the frequency was increased to five times a week, and all three lesions treated. Gradually, two lesions diminished in size. Treatment was continued until there was no clinical evidence of residual tumor at these sites (19 weeks) repeat biopsies showed only a focus of dysplastic cells with no invasion (dorsum, left foot), and epidermal hyperplasia with no significant cytological atypia (outer aspect, right lower leg) Neither now showed evidence of invasive SCC. After 16 months there was no recurrence of either lesion. The third lesion (right lower leg,) did not respond to topical imiquimod and was later surgically excised. Hope this helps Matador 89

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