Nephrotic Syndrome

Question: What is the latest treatment system for nephrotic syndrome in children ? What is the latest treatment for the nephrotic syndrome in children ?

Answer: The goals of treatment are to relieve symptoms, prevent complications and delay progressive kidney damage. Treatment of the causative disorder is necessary to control nephrotic syndrome. Treatment may be required for life. Corticosteroid, immunosuppressive, antihypertensive, and diuretic medications may help control symptoms. Antibiotics may be needed to control infections. Angiotensin converting enzyme (ACE) inhibitors may significantly reduce the degree of protein loss in the urine and are therefore frequently prescribed for treatment of nephrotic syndrome. If hypertension occurs, it must be treated vigorously. Treatment of high blood cholesterol and triglyceride levels is also recommended to reduce the risk of atherosclerosis. Dietary limitation of cholesterol and saturated fats may be of little benefit, as the high levels which accompany this condition seem to be the result of overproduction by the liver rather than from excessive fat intake. Medications to reduce cholesterol and triglycerides may be recommended. High-protein diets are of debatable value. In many patients, reducing the amount of protein in the diet produces a decrease in urine protein. In most cases, a moderate-protein diet (1 gram of protein per kilogram of body weight per day) is usually recommended. Sodium (salt) may be restricted to help control swelling. Vitamin D may need to be replaced if nephrotic syndrome is chronic and unresponsive to therapy. Blood thinners may be required to treat or prevent clot formation.

Question: Are plasma transfusions indicated for a patient with nephrotic syndrome? he has acquired nephrotic syndrome due to the anticonvulsant medication given to him (he has brain cancer and is going through chemo and radio). He won't excrete more than 2cc a time and is being given Lasix. Doctors came up with the idea of giving him fresh plasma transfusions to help him with the fluid retention. Isn't this against indications?

Answer: prob ok............

Question: Is it ok to take AZO for Interstitial Cystitis if I have Nephrotic Syndrome? Is it ok to take an over the counter medicine such as AZO containing Phenazopyridine Hydrochloride if I have Nephrotic Syndrome? I have Interstitial Cystitis and need to take something for the pain, but my health insurance has expired, any help would be greatly appreciated!

Answer: Call your nephrologist. You can also ask the pharmacist.

Question: What is the treatment of steroid dependant nephrotic syndrome? Age of patient is 2 years 10 months, responded very quickly to steroids initially. Developed proteinuria within 2 weeks of completion of steroid therapy.

Answer: the response to steroids is good ,he will continue on it with an adjusted does to minimum effective to avoid stunting the growth ,if relapses re occur they may supplement with cytotoxic drugs like azathioprine,of course necessary supllementation ,the course of disease has relapses remissions and cure ,u never know where it stops and cant predict the prognosis ,for every case the response varies ,.and the outcome

Question: Im a Kidney Transplant and I want to start a foundation to help children with Nephrotic syndrome..? 1. What is the best way to get sponsors? 2. Do I need to register it to the government? 3. How can I build trust/establish credibility to the people? 4. Anybody out there who is willing to help financially? or in any way?

Answer: Here's a free management library which should answer most of your questions http://www.managementhelp.org/ And, here's a list of Grant sources http://www.intergate.com/~rclowney/g739.htm And, here's a list of helpful reading material http://www.intergate.com/~rclowney/tools.htm Good Luck!

Question: Is there anyone out there that knows anything about the diet for Nephrotic Syndrome? I was recently diagnosed, but I'm having trouble figuring out what I can still eat and what I can't. The sodium part is pretty strait forward, but finding info on phosphorus in foods has been a pain. What else do we have to watch out for?

Answer: Dietary recommendations: Limit high protein animal foods to 1 oz per meal (preferably lean cuts of meat, fish, and poultry) Limit high phosphorous foods such as cheese, cooked dried beans and peas, nut butters, soy, tofu, yogurt, and certain soft drinks. Limit high potassium vegetables and fruits such as artichokes, avocado, bamboo shoots, beets, brussels sprouts, chard, greens (such as beet and collard), kohlrabi, okra, parsnips, potatoes, pumpkin, rutabaga, spinach, sweet potatoes, tomatoes, tomato juice, tomato sauce, wax beens, winter squash, yams, apricots, bananas, dates, honeydew, nectarines, oranges, prunes. Avoid saturated fats and eat unsaturated fats in moderation. Eat low-fat desserts only. Monitor fluid intake, which includes all fluids and foods that are liquid at room temperature.

Question: Need good info from and Org or Gov site on Childhood Minimal Change Nephrotic Syndrome can you help? I'm also looking for Steriod Resistant Childhood Nephrotic Syndrome.

Answer: Sorry your baby has this. I know he/she is probably not a baby literally but they are always your"baby". http://www.kidney.org/ http://en.wikipedia.org/wiki/Minimal_change_disease http://www.kidcomm.org/ http://www.clarian.org/ADAM/doc/HealthIllustratedEncyclopedia/1/000496.htm http://www.nephcure.org/ http://www.pediatriconcall.com/fordoctor/diseasesandcondition/PEDIATRIC_NEPHROLOGY/steroid_resistant_nephrotic_syndrome_chilfren.asp This should get you started. God bless and help you and your child through this.

Question: What's the percentage of people with nephrotic syndrome? Does anyone know? Worldwide or in the UK? I have it and all I've been told is that it's rare. Just wondering. ^_^ Thank-you.

Answer: Incidence (number of new cases per year) Every year, about two in every 10,000 people experience nephrotic syndrome, which is around 10,000 sufferers in the UK (0.02%). Prevalence (number of cases at any point in time): Difficult to establish as the syndrome is often due to some other condition

Question: What is the main cause of Nephrotic Syndrome? My son developed it at age two, and we don't know the cause. He is almost six now and it seems to be getting worse

Answer: Nephrotic syndrom is the end result of a variety of diseases that damage the capillaries of the glomerulus (the place where urine formation begins.) Factors causing NS include any disorder that may affect the glomerulus, including immunologic disorders, toxic injury to the kidneys, neoplasms, metabolic abnormalities, infections, and diseases of the vascular system. Causes are classified according to the changes found in the capillaries of the glomerulus when examined by electron microscopy. Clinically, NS leads to the loss of a large amount of protein in the urine, which in turn leads to edema (fluid retention). Adrenal cortical steroids have a dramatic immediate effect on the condition but their use does not alter the survival rate.

Question: What kind of meds and what dosage do they give for nephrotic syndrome?

Answer: Use of an angiotensin-converting enzyme (ACE) inhibitor, such as enalaprilSome Trade Names VASOTEC , quinaprilSome Trade Names ACCUPRIL , or lisinoprilSome Trade Names PRINIVIL ZESTRIL , or an angiotensin II receptor blocker (ARB), such as candesartanSome Trade Names ATACAND , losartanSome Trade Names COZAAR , or valsartanSome Trade Names DIOVAN , alone or in combination is the mainstay of both prevention and treatment. When a person with a disease such as systemic lupus erythematosus or diabetes mellitus has mild or moderate proteinuria, an ACE inhibitor or ARB is used as soon as possible because it may prevent proteinuria from increasing and kidney function from worsening. When a person who already has nephrotic syndrome is treated with an ACE inhibitor or ARB, symptoms may improve, the amount of protein excreted in the urine usually decreases, and lipid concentrations in the blood are likely to decline. However, these drugs can increase the potassium levels in the blood in people who have moderate to severe kidney failure, which can cause potentially dangerous heart rhythm abnormalities.

Question: Nephrotic Syndrome? Is there a permanent cure for nephrotic syndrome other than just outgrowing it? If there isn't then at what range of age does one outgrow it? I'm 12 and I think this syndrome is quite annoying because of its relapses, and drinking medicine all the time.

Answer: I know how hard it is for you,but you have to be very patient.... My son is almost 8 years old and has been suffering nephrotic syndrome for 5 years now. I live in Lebanon and recently took him to Australia to see if there was better medication there but i guess it is all the same.... My son is a frequent rellapser which makes it difficult to let him know hy we have to increase his medicine dosage Please be patient you're almost through cuz at the age of 13 or 14 you will outgrow this disease Drink plenty of milk because that will help your body not be affected by the prednisone Please tell me if you have any helpfull tips please let me know.....

Question: i have a kidney disease that is called nephrotic syndrome and i have leakage that gets in my underwear. i was? wanting to know if there is anyway i can help my kidneys from doing that? and i was wanting to know why that does that. thanks much.

Answer: You should get to a specialist... I thought I had the same thing... but I had Amyloidosis.... check on the enet at Amyloidosis.org.... Good luck Grant M from Pennsylvania

Question: How does the nephrotic syndrome cause (exudative) ascites? thanks sami!

Answer: actually sami is incorrect. nephrotic syndrome causes proteinuria which means your serum proteins like albumin are spilling out into your urine. when albumin levels are low, your serum oncotic pressure is decreased and the oncotic forces will drive free water into the interstitium. that's why you have edema and ascites, from the change in oncotic forces. and by the way, that's a transudative ascites. exudative ascites would occur from infection or malignancy.

Question: Is there any medicine for MCNS (Minimal Change Nephrotic Syndrome ) I am a patient of MCNS for 9yrs? Steroid dependent. will steroid give any harm. Relapse twice in a year. more details can be given. Pls help me. presently tappering stage of steriod on 10 mg Alternate days Now I get 1+ on Albumin test. what should I do . Should I increase dose to 60 mg wehere I started.

Answer: 2 relapses in a year are not frequent. If relapses are 2 or more in 6 months or 3 or more in a year, then you are steroid dependent. Side effects to watch for: Hypertension, moon face, buffalo hump, purple striae, low calcium, gastritis or peptic ulcer. You must be on alternate day low dose steroids. If you become steroid dependent or have side effects, you will be switched to cyclophosphamide. This is a cytotoxic drug with potential side effects like bone marrow depression and hemorrhagic cystits (inflammation of the urinary bladder. Male sterility is also a potential side effect. For the present, you must continue steroids. With time, the relapses will stop and you will be perfectly all right. 1+ albumin is OK. Do not increase the dose.

Question: smoking will create any specific problem to Minimal change nephrotic syndrome? I am a smoker for the past 25 years an average 10-15 cig in a day.

Answer: Smoking causes many health problems and worsens any existing ones.

Question: i have nephrotic syndrome and i am wanting to know what would make me hurt every morning trying to get out of? bed and trying to turn over in the night or in the morning when i first wake up. i have sever pain when i try to turn over where my kidney and ribs are and cant hardly move. hurts in ribs and in the front around my front ribs and stomach also. thanks much!

Answer: I could be from enlargement of the kidneys (nephromegaly) with pain being referred along nerves to the sides and front. It could be that there may be some stone formation that is producing pain, with backup of urine and distention of the kidney pelvis or ureters If this pain is new, you should call your nephrologist for advice.