Mediterranean Fever Familial

Question: If familial mediterranean fever is left untreated can it cause death? He also has a secondry infection of vasculitis. How long is life expectency if you don't have treatment for both? What method of treatment is there? Can it make you feel nauseous? I'm wondering cause my friend's kid was just diagnosed with it and he's only a couple years old.

Answer: I know someone who has it. It is fatal if you don't have treatment. As for vasculitis as far as I know that can be fatel to. It's blood vessels so it can evently lead to death. I don't know how long life expectency is. It's not like 10 days or something like that. It's not short but not 10 years. It's somewhere in between. Talk the family into getting treatment. It's a tiney pill the kid has to make, smaller than M and M's. It's not worth dying over. It would effect the kid in any other major way. He can still have a normal life. With treatment life expetency as the same for him as it is for the healthiest person alive.

Question: Familial Mediterranean fever & getting pregnancy? Three years ago I've been diagnosed with Familial Mediterranean fever "FMF". The doctor asked me to take 1mg colchicine a day to help reduce/prevent FMF attacks. But since I've been trying to conceive, I haven't taken a colchicine pill in over a year, and as a result I suffer from FMF attacks regularly once every month. I stopped taking the colchicine because I read that it temporarily reduces fertility. We've now been trying to conceive for 1 year and I am wondering could the monthly FMF attacks are stopping me from getting pregnant, or what? The problem is that I cannot find an FMF specialist where I live because FMF is not a familiar disease in USA, because FMF only effect people originating from around the Mediterranean Sea (Armenian, Arabs, Jews, Turks..) Is anyone familiar with this?

Answer: It is definitely possible that FMF attacks are preventing you from getting pregnant, as this is one side effect of the disease. Inflammation caused by FMF can affect your reproductive organs. About one-third of women with this condition are infertile, and about 25 percent of those who become pregnant experience miscarriages. Thus, taking colchicine or other anti-inflammatory medications HELPS you to get pregnant. Colchicine therapy is not associated with an increased risk of infertility or of abnormalities in a developing baby. Omega-3 is also an effective anti-inflammatory that can be taken in place of colchicine. Some people with FMF also notice that their attacks are lessened by following a low-fat diet. A diet high in hydrogenated and saturated fats increases inflammation in the body and omega-3 and omega-9 fatty acids [from salmon and other ocean fish and techina] reduce inflammation.

Question: Is it safe to use colchicine as a treatment for Familial Mediterranean fever (FMF) during pregnancy.?

Answer: Wow! That's a very serious condition during pregnancy and certainly a little too serious for this kind of forum. ANYTHING that is ingested to treat an illness during pregnancy should always be assessed, monitored, treated and discussed with a doctor during pregnancy. What we may normally just deal with on our own in life, becomes far more significant while being pregnant. There are so many things to consider, such as what trimester you are in, the severity of exposure to illness as well as the symptoms and affects of the illness...not to mention the amount of colchicine being used and the risks/side affects that may be associated with that use. My advice would be to call your doctor's office right away. You may not have to be seen, a medical assistant or nurse may be able to answer your question immediately. You can also consider running this question past your local pharmacist (as, they tend to have information of your medical history just as your doctor does). Congratulations on the pregnancy- best of happiness and health to you! :)

Question: what is the Familial Mediterranean Fever? and what is the cure?is available in canada??

Answer: Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder that affects groups of patients originating from around the Mediterranean Sea. It is prominently present in the Armenian people (up to 1 in 7 affected), Sephardi Jews (and, to a much lesser extent, Ashkenazi Jews), people from Turkey, and the Arab countries. Symptoms usually begin between age 5 and 15. Inflammation in the lining of the abdominal cavity, chest cavity, skin, or joints occurs, along with high fevers that usually peak in 12 to 24 hours. Attacks may vary in severity of symptoms, and people are usually symptom free between attacks. There are 7 primary sites of the attacks: 1) Abdominal attacks - 95% of all patients 2) Joint attacks, occurring in joints, mainly of the legs - 75% 3) Chest attacks with pleuritis (inflammation of the pleural lining of the lungs) and pericarditis (inflammation of the pericardium around the heart). Pleuritis occurs in 40%, but pericarditis is rare. 4) Scrotal attacks due to inflammation of the tunica vaginalis. This occurs in up to 5% 5) Erysipeloid (a skin reaction on the legs, rare in isolation) 6) Myalgia (rare in isolation) 7) Fever without any symptoms (25%) Attacks are self-limiting but normally require medication and analgesia (pain killer). Since the 1970s, colchicine, a drug used mainly for gout, has been shown to decrease attack frequency in affected individuals. There is no specific test to diagnose the disease. The cause is unknown. I'm not sure what you are asking is available in Canada, the disease or the cure. The disease is wherever people of this descent settle. There is no cure in any country.

Question: which is the best treatment for Familial Mediterranean Fever (FMF)?

Answer: Familial Mediterranean fever From Wikipedia, the free encyclopedia Jump to: navigation, search FMF redirects here. You may be looking for Funkmaster Flex. Familial Mediterranean fever ICD-10 E85.0 ICD-9 277.3 Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder that affects groups of patients originating from around the Mediterranean Sea (hence its name). It is prominently present in the Armenian people (up to 1 in 7 affected), Sephardi Jews (and, to a much lesser extent, Ashkenazi Jews), people from Turkey, the Arab countries and Lebanon. Contents [hide] 1 Clinical symptoms 1.1 Attacks 1.2 Complications 2 Diagnosis 3 Disease mechanism 3.1 Pathophysiology 3.2 Genetics 4 Treatment 5 History 6 References 7 External links [edit] Clinical symptoms [edit] Attacks There are seven types of attacks. 90% of all patients have their first attack before they are 20 years old. All develop over 2-4 hours and last anytime between 6 hours and 4 days. Most attacks involve fever: Abdominal attacks, featuring abdominal pain affecting the whole abdomen with all signs of acute abdomen (e.g. appendicitis). They occur in 95% of all patients and may lead to unnecessary laparotomy. Incomplete attacks, with local tenderness and normal blood tests, have been reported. Joint attacks, occurring in large joints, mainly of the legs. Usually, only one joint is affected. 75% of all FMF patients experience joint attacks. Chest attacks with pleuritis (inflammation of the pleural lining) and pericarditis (inflammation of the pericardium). Pleuritis occurs in 40%, but pericarditis is rare. Scrotal attacks due to inflammation of the tunica vaginalis. This occurs in up to 5% and may be mistaken for acute scrotum (i.e. testicular torsion) Myalgia (rare in isolation) Erysipeloid (a skin reaction on the legs, rare in isolation) Fever without any symptoms (25%) [edit] Complications AA-amyloidosis with renal failure is a complication and may develop without overt crises. AA (amyloid protein) is produced in very large quantities during attacks and at a low rate between them, and accumulates mainly in the kidney, as well as the heart, spleen, gastrointestinal tract and the thyroid. There appears to be an increase in the risk for developing particular vasculitis-related diseases (e.g. Henoch-Schoenlein purpura), spondylarthropathy, prolonged arthritis of certain joints and protracted myalgia. [edit] Diagnosis The diagnosis is clinically made on the basis of the history of typical attacks, especially in patients from the ethnic groups in which FMF is more highly prevalent. An acute phase response is present during attacks, with high C-reactive protein levels, an elevated white blood cell count and other markers of inflammation. In patients with a long history of attacks, monitoring the renal function is of importance in predicting chronic renal failure. A genetic test is also available now that the disease has been linked to mutations in the MEFV gene. Sequencing of exons 2, 3, 5, and 10 of this gene detects an estimated 97% of all known mutations. [edit] Disease mechanism [edit] Pathophysiology Virtually all cases are due to a mutation in the MEFV gene, which codes for a protein called pyrin or marenostenin. This was discovered in 1997 by two different groups. Various mutations of this gene lead to FMF, although some mutations cause a more severe picture than others. Mutations occur in exons 2, 3, 5 and 10. The function of pyrin has not been completely elucidated, but it appears to be a suppressor of the activation of caspase 1, the enzyme that stimulates production of interleukin 1β, a cytokine central to the process of inflammation. It is not conclusively known what exactly sets off the attacks, and why overproduction of IL-1 would lead to particular symptoms in particular organs (e.g. joints or the peritoneal cavity). [edit] Genetics The MEFV gene is located on the chromosome 16 (16p13). The disease inherits in an autosomal recessive fashion. Therefore, two asymptomatic carrier parents have a 25% chance of a child with the disorder. FMF patients who marry a carrier or another FMF patient have a 50% and 100% chance, respectively, in having a child with FMF. [edit] Treatment Attacks are self-limiting, and require analgesia and non-steroidal anti-inflammatory drugs (such as diclofenac). Since the 1970s, colchicine, a drug otherwise mainly used in gout, has been shown to decrease attack frequency in FMF patients. The exact way in which colchicine suppresses attacks is unclear. While this agent is not without side-effects (such as abdominal pain and muscle pains), it may markedly improve quality of life in patients. The dosage is typically 1-2 mg a day. Development of amyloidosis is delayed with colchicine treatment. Interferon is being studied as a therapeutic modality.

Question: Has anyone been diagnosed with Familial Mediterreanean Fever? If so, how do you cope? Familial Mediterranean Fever is a rare genetic disorder that mimics the symptoms of severe flu, chronic fatigue syndrome, and fibromyalgia.

Answer: I certainly would prefer not to have it but... I'm on Colchicine 1 mg a day. I once was on 1.5 mg a day (for 15 years) and I'm allowed to go up to 2 mg. That's the main thing. The crises are by far less frequent and less severe. I purposedly losed weight because fat releases certain hormones linked to inflamation. It didn't help much for FMF, but did some wonders with girls. I do not know why but certain food seems to help, others to be bad : Bad : whole cheese especially when taken with beer. Dont' ask me why I was doing that. Good : european, heavy, coffee, good, heavy, red wine. White wine does nothing. Alcools does not help - except for my mood. I try to live a healthy life, and to do sport when I can. A good thing to do is to learn when the crisis is coming and immediately take a second pill or half a pill (1mg, or 0.5 mg) on that very day. It wipes off some of the crises. NB - I use the french brand of Cochicine. Seems to work better (Im french but I do not live in France). Colchimax, the one with some antidiarhetic in it does not work (on me, and some others).