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Metabolic Alkalosis
Get the facts on Metabolic Alkalosis treatment, diagnosis, staging, causes, types, symptoms. Information and current news about clinical trials and trial-related data, Metabolic Alkalosis prevention, screening, research, statistics and other Metabolic Alkalosis related topics. We answer all your qestions about Metabolic Alkalosis.
Question: How does excessive vomitting cause metabolic alkalosis and why normal saline can be used to correct it?
Answer: Your body has a finite amount of hydrogen ions. If you were to lose those ions through vomiting gastric acid you might for a short while have an excess of bicarbonate and the hyperventilation associated with that much vomiting would further increase the pH. But this condition is self limiting.
As to n/s to correct it I'm not sure how that would help unless it was to increase the chloride content and cause a metabolic acidosis to compensate.
Question: can anyone help this is for a friend,its regarding metabolic alkalosis, gene mutation plz.? hi a firend of mine needs helps on tis he needs to know this
"gene can be deleted/mutated by Metabolic upset/Metobolic Alkalosis or Hypochloremic metabolic alkalosis.
if anyone can help ill give 10 points to the most helpfull and informative answer , as his little girl is ill and he needs to know about this, thankyou.
hi yeah thanks for the answer but he needs info , on if the there is a gene mutation and also on gene deletion plz, he has info on metaboloic alkalosis but not gene mutation or deltion of it.
thanks though for your help, i really need more details on the above gene detetion etc. thanks though.
Answer: The short answer to your question is yes, it can be caused by a gene mutation, see the link below, but please read on.
http://www.ncbi.nlm.nih.gov/entrez/query…
Metabolic alkalosis describes an imbalance in the acid-base levels in the blood. It occurs for many reasons, including genetic causes which can be long term problems, but also as a result of other problems for example problems with the bowel which can be temporary. Treatment will obviously depend upon the cause.
Since your friend has already been told that his daughter has metabolic alkalosis then I assume that she is already being investigated for any underlying cause. I don't want to patronise you or dismiss your question, but in order to answer this question completely a lot more information would be required. Your friend's doctors will be able to provide much more information as investigations progress, but I understand his frustration whilst waiting with a sick daughter.
ADDED:
There was a typo in the part you added [detetion]- is it the deletion or detection you are specifically enquiring about?
The detection will involve blood tests and is likely to take some time (depending upon the lab), unless the problem is as a consequence of a chromasomal abnormality which could be identified quicker. There are several different genetic mutations (such as deletions) which can cause the metabolic alkalosis syndrome, if that is the cause. You would need to know which mutation or deletion the child has before seeking specific information on it and once that is known, the geneticist investigating the child will be able to give far more information. Hope that helps a little more. Good luck
Question: Metabolic alkalosis from IRON? Could iron accumulation in our bodies lead to metabolic alkalosis?
Answer: if the iron caused cirrhosis of the liver, then the liver's ability to destroy aldosterone could occur. High levels of aldosterone promote metabolic alkalosis.
Poke around in the Merck Manual:
http://www.merck.com/mmpe/sec12/ch157/ch…
http://www.merck.com/mmpe/sec03/ch026/ch…
Question: metabolic acidosis or alkalosis? A patient exhibits elevated urine ammonia and increased rate of respiration. Does the patient have metabolic acidosis or metabolic alkalosis?
Answer: From the symptoms, it seems to be metabolic acidosis.
Question: Metabolic alkalosis/ Respiratory acidosis Question? Could someone please help me with these 2 questions? Thanks in advance. And could you also please explain why?
The treatment for respiratory acidosis is:
A) intravenous bicarbonate infusion
B) Breathing into a paper bag
C) intravenous administration of ammonium chloride
D) Any of the above
The treatment of metabolic alkalosis is:
A) intravenous bicarbonate infusion
B) Breathing into a paper bag
C) intravenous administration of ammonium chloride
D) Any of the above
Answer: The treatment for respiratory acidosis is none of the above. Hypoventilation needs to be corrected if possible, and that may be as simple as shaking an oversedated overdose patient and reminding him to breathe, or it may require mechanical ventilation.
Metabolic alkalosis is common as dirt but usually mild and in no need of treatment. It's often caused by excessive vomiting or nasogastric suction, and those people normally get IV's with sodium and potassium chloride in them, the chloride replacement incidentally correcting the alkalosis. In theory a few severe cases might need treatment with ammonium chloride, but if you're planning to get rich doing this, you're better off going into dentistry for chickens, hens' teeth being more common.
Once upon a time, breathing into a paper bag was recommended for respiratory alkalosis (hyperventilation syndrome), the idea being to have the patient rebreathe some of the exhaled carbon dioxide. These days, we just give them benzodiazepines. The chill pills work better and with less fuss.
Bicarbonate infusions can correct metabolic acidosis, but there are often more problems presented than solved by the treatment, and it's essential that the patient be able to blow off the excess carbon dioxide that eventually results (Henderson-Hasselbach). IV fluids, general support, and correction of the underlying problem tend to be a larger focus.
Question: Is normal pH, but abnormal Pco2, & -HCO3:H2CO3 levels "compensated" respiratory/ metabolic acidosis/alkalosis? My professor has asked me to solve a few arterial blood gas values for a lab report, but I have been having difficulty with the scenario in my question. Is this setup always going to be considered "compensated"? I know that the respiratory/metabolic, acidosis/alkalosis conditions are dictated by the given values for Pco2, the -HCO3 to H2CO3 ratio, and pH range, but I have only been exposed to situations where the pH is either too high or too low and the other readings are abnormal, not where pH is normal and the other readings abnormal.................I have been searching everywhere, please help!!!!!!!
Answer: Monocube kind of has the right idea, but not really. The first thing you look at is the pH. Normal range is 7.35 - 7.45, with the absolute being 7.4. the lower the #, the more acidic it is, and the higher it is the more alkalotic.
The next thing you look at is the PaCO2. Normal = 35 - 45. When CO2 mixes w/ H20, you get carbonic acid, so increased PaCO2 will cause the pH to be more acidic (lower pH), decreased - more alkaline (higher pH).
Then you look at the HCO3 level. Normal is 22-26. Bicarb is alkaline. The higher the bicarb level, the more alkaline (higher pH) and decreased bicarb = more acidic (lower ph).
So, lets make up a blood gas:
pH 7.28 PaCO2 74 HCO3 26 (we'll forget the other results for now & concentrate on this part)
Ok, so we see that the pH is low, so this is an acidic result. Now - what's causing it? The respiratory system, or the kidneys? Our CO2 (respiratory) is high, which means acidic. The bicarb is normal, so it is not a metabolic (kidney) problem. This is a respiratory acidosis.
And you want to know about compensation...compensated means that it is a chronic problem. Something that has been going on for awhile, and the body has had time to fix the problem, and return the pH back to the normal level.
The example we have above is an acute problem. The bicarb level is normal. It takes at least 24 hours for the kidneys to try to compensate for a respiratory problem. This is an acute respiratory acidosis.
If we change the values - pH 7.33, same PaCO2 - 74, and HCO3 of 32, then we see that the kidneys have now started to fix the problem. Our pH is still acidic, still caused by a respiratory issue, but the bicarb is now elevated, so this is a partially compensated respiratory acidosis.
Once again, changing values to pH 7.37, PaCO2 74, HCO3 36. Now our pH is in the normal range. BUT, this is where people get messed up - you have to remember that the absolute normal is 7.40. This pH is on the acidic side, even though it is in the normal range. So then you look at the other values. the CO2 is very high, but so is the bicarb.
I have seen Doctors and nurses who are unfamiliar with blood gas interpretation freak out on a gas like this. Is this patient in respiratory distress? NO! let me explain why. This is a compensated respiratory acidosis. The pH is back in the normal range! This is a typical blood gas for a COPD patient. This is where they "live". They retain CO2, their levels are always high, so the kidneys "compensate".
If you have more questions, feel free to email me at mike.marlow@yahoo.com I hope this helps you.
Question: Respiratory Acidosis/ Metabolic Alkalosis? Could someone please help me with these 2 questions? Thanks in advance. And could you also please explain why?
The treatment for respiratory acidosis is:
A) intravenous bicarbonate infusion
B) Breathing into a paper bag
C) intravenous administration of ammonium chloride
D) Any of the above
The treatment of metabolic alkalosis is:
A) intravenous bicarbonate infusion
B) Breathing into a paper bag
C) intravenous administration of ammonium chloride
D) Any of the above
Answer: Respiratory acidosis due to decreased ventilation of the pulmonary alveoli, leading to elevated arterial carbon dioxide concentration (PaCO2).
Metabolic acidosis is a state in which the blood pH is low (less than 7.35) due to increased production of H+ by the body or the inability of the body to form bicarbonate (HCO3-) in the kidney, its causes are diverse.
So Bicarb will cure both, but NH4Cl is sometimes used inMet. Acid if renal function is OK
Question: Metabolic alkalosis question? What buffers are used by an organism to prevent excessive alkaline--alkalosis? I was thinking it had to do with the kidneys, but I do not know the process.
Answer: Your kidneys work very slowly to either retain or excret bicarb to change the amount of alkalinity in the blood. The 'buffer' you are talking about would be that a person would naturally start to slow respiration and/or become hypoponic (shallow respiration) in order to retain carbon dioxide which in the blood is an acid and would then help to balance the pH of the blood back to the mid range. Conversely of the person was acidotic they would breath deeply and rapidly and of occur the kidneys would slowly work to retain the bicarb to balance the pH. Higher Bicarb levels are most commonly seen in patients with renal failure and COPD patients with a history of CO2 retention.
Question: What is a good way to remember ABGs.....and metabolic acidosis/alkalosis and respirtatory acidosis/alkalosis? Explain....I have a test over fluids and elecrolytles in the morning...if anyone has any good notes or good ways to remember these please do tell.....
Answer: The best way is to learn what they're all about. Acid-base balance should not be broken down to a mnemonic. Study and stop looking for easy ways to get through a test. You will need this knowledge in your profession. Don't put it off. It's not really that hard to understand.And if anyone on here gives you a simple way to remember acid-base balance they're not doing you any favors. Look up the Henderson-Hasslebach equation. If you're smart enough to be asking this question then you will understand it a lot better by learning the basics.
God bless.
Question: Congestive Heath Failure and Metabolic Alkalosis? Please Help? I thought CHF should lead to metabolic acidosis because the CO2 retention, and renal failure to excrete Hydrogen ion..............
Answer: Right heart failure caused by conditions like pulmonary hypertension and hepatic disorders may cause alkalosis.
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