Hemophilia

Question: Hemophilia is a sex linked. A hemophiliac man marries a woman who is neither hemophiliac nor a carrier of tra? Hemophilia is a sex linked. A hemophiliac man marries a woman who is neither hemophiliac nor a carrier of trait. Select the statement that best describes their possible offspring. A) All females will carry the gene for hemphilia, but will not have the disease. B) All male children will have hemophilia. C) All female offspring will have hemophilia. D) All male will be normal. E) A and D are correct. Any help will be fine.

Answer: it's E Understand that if it is a sex linked disease this means it it only carried on x chromosomes and is recessive (recessive means its wont "show up" unless there are two x chromosomes with that disease). so it can only show up in males, even though females may carry the gene. And since the females x chromosome is not "infected"- when it is combined with an x chromosome that IS infected it will "cover" it up (since the infected x chromosome is recessive) that chromosome, therefore it will not affet males either (in this case) edit: this was in ur 12th grade course?? it was in my 7th grade course...

Question: What is the probabilty that the child will have hemophilia? Hemophilia A and color blindness are two X-linked recessive trais, whose loci are 10 cm apart. The dad is a normal and the mom is normal but she has a father with hemophiliac and a mother with color blindness. The mother parents are homozygous/hemizygous. What the probability that the couple first child has hemophilia only? Has both color blindnesss and hemophilia? Or have neither?

Answer: First, you need to establish the genotypes of the parents. You're told the traits are x-linked and recessive. This means the mother -must- be homozygous recessive if she displays any of these traits in her phenotype, but she doesn't. So she must be heterozygous for both traits (Cc for colourblindness and Hh for hemophilia, making her genotype CcHh). The dad is simple because he only has one x-chromosome. Since he displays neither trait in his phenotype, he cannot even be a carrier of the recessive trait (otherwise he would display it), thus his genotype must be CH and he does not contribute to the conditions in question in his children. Once you know this, you can determine what will happen. If the child is a girl, she must be homozygous recessive in order to have either trait, but this is impossible since the father can't give the recessive gene. Thus, a girl -cannot- have colourblindness or hemophilia. Hemo only: 0% Both: 0% Neither: 100% If the child is a boy, he only needs the recessive from his mother to exibit the trait. He has a 50% chance of getting either one (and a 50% chance of -not- getting it, for the third question), thus: Hemo only: 50% Both: 0.5*0.5 = 25% Neither: 25% Is this clear for you? If not, ask, I'll explain whatever you need explained. I hope I've helped you, good luck!

Question: Can a virgin with hemophilia engage in sex or will deflowering her hymen cause her to bleed to death? If it is impossible for her to ever engage in sex, then how did the British royal family ever propagate itself if many members of said family had hemophilia?

Answer: Hemophilia is an X-linked disease. Females have two X chromosomes, but males have only one X, therefore males lack a 'back up' copy for the defective gene. Females are therefore almost exclusively carriers of the disorder, they have no symptoms but they pass it on to their male children. Therefore, they have no problems engaging in sex. Hope this helped!

Question: What is the frequency of women that carry hemophilia? I'm doing a project on hemophilia and i need to know how many people carry the disease. If anyone knows the number of women that carry the gene for hemophilia, PLEASE let me know. Thanks!

Answer: Corinne, It is not rare to see a women reach child bearing age with hemophilia. I have mild hemophilia. I am a symtomatic carrier. Means I am a carrier with mild hemophilia. I have heavy menstration cycles and have had 3 children. One with severe hemophilia. So it is not unusual for a women with hemophilia to live. We do not bleed any more it just takes longer to clot. It is controllable also. nikixox7, Here is what the hemophilia foundation says: There are several types of bleeding disorders that affect women. von Willebrand disease (VWD) is the most common inherited bleeding disorder and may affect up to 2.5 million American women. Women may also be “symptomatic carriers� of hemophilia, meaning that in addition to carrying the gene, they also exhibit symptoms similar to mild hemophilia. All of the rare factor deficiencies, which include factor I, II, V, VII, XI and XIII, can also result in bleeding among men and women. Aside from the fact that women have similar symptoms to men with bleeding disorders, they can also experience added obstetric and gynecological complications. VWD and other bleeding disorders are particularly troublesome for reproductive-aged women. Heavy and prolonged menstrual bleeding, also known as menorrhagia, can lead to serious complications if left untreated. Other common symptoms include recurrent nosebleeds, easy bruising, bleeding from the digestive or urinary tract and excessive bleeding from the mouth or gums. Some doctors may not be familiar with bleeding disorders affecting women, making a definitive diagnosis elusive. It is common for bleeding symptoms to be attributed to other causes or to simply go unexplained. The troubling aspect to this problem is that non-surgical treatments are available for these conditions. In cases where a woman with a bleeding disorder (or symptomatic carrier) becomes pregnant, she should see an obstetrician as soon as possible. This will ensure that the doctor can consult with the local hemophilia treatment center to provide pre- and postnatal care for the woman and her baby. Decisions about what medical and surgical options to pursue should be based on personal preference, family planning goals and severity of bleeding problems. In 2000, the National Hemophilia Foundation (NHF) launched a new education program, “Project Red Flag (PRF): Real Talk About Women’s Bleeding Disorders.� PRF is a national awareness campaign to target undiagnosed women with bleeding disorders and their doctors. The campaign includes public outreach, grassroots community efforts, professional education programs and publications. To learn more about PRF visit the NHF Web site at www.projectredflag.org. Women who suspect they may have a bleeding disorder should contact NHF for information about where to go for help and what to discuss with a doctor. Information and referrals to healthcare providers are also available through HANDI at 800-424-2634 or handi@hemophilia.org.

Question: Hemophilia: What are the symptoms, diagnosis, genetic patterns of inheritance, and cure/ treatment of it? I just want to know what the symptoms of hemophilia are, the diagnosis, the genetic patterns of inheritance, and whether or not there is a cure (is there one being worked on?). Thank you for your help!

Answer: Hemophilia is a genetic disorder. The symptoms are easy bruising, prolonged bleeding and in some cases can lead to death. Most hemophiliacs fall under the heading of Factor 8 ( hemophilia A) or Factor 9 (hemophilia b). The factor simply put is the clotting that they are lacking. Factor 8 is the most common. It is important to remember that like many things there is not just one type of Hemophilia. Some hemophiliacs may only need treatment for a major injury or surgery. While others may get muscles and joint bleeds and not know how the bleed started. Treatment: Mild hemophiliacs may only get treatment when need to before a surgery. While those with severe hemophilia may treat 3 times a week regardless if there is a bleed or not. This is done to improve the quality of life. Many hemophilics are often taught to treat at home. This means finding a vein and sticking yourself with a needle. Factor 9 hemophiliacs are often given Benfix. While factor 8 hemophiliacs are now getting Whety more often as it just hit the market in Jan 2008. Both are VERY VERY expensive. Cure: There is no cure for hemophilia. Much hope was put into genetic engineering and still is however it still seems far away. Oddly enough hemophilia has been cured in mice. Researchers in short with through the mice liver and forced the body to produce the lacking clotting agent. It is important to note that while promising mice and humans are worlds apart. Sources are listed below I hope this helps.

Question: What is the chance that their first child will have hemophilia? Hemophilia is an X-linked recessive disease that prevents blood clotting. If a woman who is a carrier for hemophilia marries a sick man, what proportion of their sons is expected to have hemophilia? What is the chance that their first child will have hemophilia? (Remember, the sex of this child is unknown until birth.)

Answer: The woman is X*X and the man is X*Y (X* is the gene for haemophilia and X is unaffected) Using the punnet square method you get: _____X*___X X*__X*X*__X*X Y__X*Y___XY So just looking at the XY's - 50% of their sons will have haemophilia. Also, if we don't know the sex, There is a 50% chance of a child having haemophilia.

Question: How is it possible for Mother Teresa to have hemophilia? Hemophilia is a sex linked genetic disease. Males carry the expression where as females are carriers for the disease. How is it possible for her to have it if she was a female?

Answer: Haemophilia is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a blood vessel is broken. Females are almost exclusively the carriers of the disorder, and may have inherited it from either their mother or father. Queen Victoria is a famous haemophiliac. She passed it on to the entire regal family.

Question: How many years til hemophilia gets less severe? I am 13 and I have hemophilia, I was diagnosed at 5. How much longer til it should get less severe?

Answer: I answered your last post. Then you posted about your science teacher. They do not know. My sons science teacher told him that cats do not sleep because they will die. (not true). So, the disease did come from royalty. And yes in some way you are related to her. We also have hemophilia in our family and it is the same. It originated from a royal family. Another person answered that it was recorded before that. They were wrong also. It is rare that your hemophilia will become less severe. Depending on if you have hemophilia A or B. My son has B and he is severe and will be the rest of his life. For our family we all have the same. It is severe. I would not listen to what your teacher says because things like this they know nothing. You should talk to your specialist about this when you go back next time they will be able to tell you if it will become less severe. You should also be getting factor for this.

Question: Where can I find hemophilia charts and statistics? I need charts of hemophilia that shows statistics such as death rates, males/females, chances of occurring, etc. I've been searching all over the internet for images, but I've barely found any.

Answer: Try typing a key word or 2 into the search box and see if it throws anything useful up: The Best Free Article Links. http://uk.ask.com/ http://www.cdc.gov/ http://www.suite101.com/ http://www.wisegeek.com/ http://scholar.google.com/ http://www.infoplease.com/ http://www.findarticles.com/ http://www.articlesbase.com/ http://vos.ucsb.edu/index.asp http://www.ezinearticles.com/ http://www.allfreeessays.com/ http://www.learnnc.org/bestweb/ http://www.articlediscovery.com/ http://www.whatreallyhappened.com/ Articles and essays http://art-bin.com/aaehome.html http://art-bin.com/art/aazartic.html

Question: How much is Insurance for someone who has Hemophilia? How much a month or year does a family or individual pay for insurance with hemophilia? What insurance company are you affliated with? For those who work for the government, would hemophilia be covered in your health care package? Thanks for all answers.

Answer: In terms of private insurance that is not given out by a job you can forget about getting coverge from them if you have hemophilia. I had over 40 rejection letters to prove it. As for insurance that is offered through someones job my own personal experience has been its the same as everyone else. It is important to note that many insurance company's have a "preexisting condition" clause. For most insurance company's this in short states that a person must not of been treaded for their pre existing condition for a year to be able to be covered for it right away. If you have been treated for a pre existing within the last year you must be insured from anywhere to 6 months to a year before the insurance company will cover it. One last thing to remember is almost all insurance company's have a "Lifetime Cap". This means that the insurance company will only up to a certain dollar amount for a person for their entire life. For many people this is almost never really an issue as it really only comes into play for those who need life long expensive treatments such as hemophilia.

Question: Hemophilia? I know that hemophilia is a genetic disorder where in the clotting is disrupted. but what essential aspect of the clotting process is effected??? can anyone help?

Answer: Hemophilia is a hereditary bleeding disorder of specific blood clotting factors. There are several types of hemophilia, including hemophilia A and B. Hemophilia A results from a deficiency (lack) of clotting factor VIII. The disorder is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. That means the disorder occurs primarily in males. Females carry two copies of the X chromosome, so if the factor VIII gene on one chromosome doesn't work, the gene on the other chromosome can do the job. Males, however, carry only one X chromosome, so if the factor VIII gene on that chromosome is broken, they will have hemophilia A. Hemophilia A is 7 times more common than hemophilia B. Hemophilia B is the result of a deficiency of clotting factor IX. The disorder is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. Thus, the disorder occurs primarily in males. Females carry two copies of the X chromosome, so if the factor IX gene on one chromosome is defective, the other can compensate. Males, however, carry only one X chromosome, so if the factor IX gene on that chromosome is defective, they have the disease. Von Willebrand disease is the most common hereditary bleeding disorder which affects both men and women. Please see the web pages for more details on Hemophilia, Hemophilia A, Hemophilia B and Von Willebrand disease.

Question: Do people with Hemophilia usually have a normal lifespan? Considering both Hemophilia A and Hemophilia B, what is the average lifespan for people who have Hemophilia? Do they usually live as long as anyone else these days? If they die a death due to the Hemophilia how the death usually occur/what causes it?

Answer: My father had Hemophelia B which is a blood disorder where you are missing FACTOR 8 which is a clotting factor that is missing with this disease. It causes internal bleeds throughout the body. It doesn't take an injury to cause it. It just occurs. It is then necessary to get blood transfusions which comes in UNITS of crio-precipitate, which must be thawed, or there are home treatments where the patient can mix their own man-made clotting factor. you must obtain it at a Pharmacy and learn to infuse it yourself if you choose to do it at home. With this Hemophelia(the one missing factor 8)it can be mild, moderate or severe. My dad's was severe. He was born in 1932 and died in 1998. In his situation, doctors told him he wouldn't live until 25, and he became the oldest living Hemopheliac in Louisville dying at 68. He beat the odds. The internal bleeding over time causes many problems, namely, crippling in the joints, damage to liver from pain meds, transfusions and blood products. Because of years of these problems my dad developed a cancer in his liver which spread and he passed away. Now days though, younger people with this have better treatment and care, than my dad did as a child so they may live even longer. (even the severe ones) This is the disease Nicholas and Alexandra's son(czar and czarina of Russia in early 1900's) had. His was severe. Richard Burton, the actor, had a very mild case. Mostly men get this disease and it is genetic. It is passed down by the mother to her sons. Her daughters most likely will be "carriers" which means the daughter then has a 50-50 chance of having a son with Hemophelia. I am a carrier. I am now 50 and chose not to have children because of this painful, and dreaded disease. My dad suffered greatly throughout his lifetime. I hope this helps!

Question: Is it possible to have facial piercings if you have hemophilia? This may sound stupid but I'm just wondering if a person with hemophilia could get facial piercings. I'm writing a story so I just wanted to know.

Answer: Sure we can. We can even have heart transplants. The key is the factor that a person with Hemophilia would take. The factor they take brings their blood clotting up to normal just any other person. Once the clotting factor is up to normal they are set to go. As far as facial piercings. It would depend on each person with Hemophilia. Some have very low clotting factors under 1% of normal others are not to bad like myself who have 19% of normal. If you need more info feel free to ask me.

Question: Can a person with hemophilia get a tattoo ? Can a person with hemophilia get a tattoo ? Would the bleeding be any problem ? Any experiences ? all great answers, can someone point me to some user experiences ? or if any hemophiliac has some tattoos, speak up :p !

Answer: I have a disease that is very similar to hemophilia, in that once I start bleeding, I just can't stop. I am under the care of a Dr. and she has me on a medication that is a nasal spray that can be taken if I fall and hurt myself or whatever. I don't know if there are any medicines that hemophiliacs are on like this. So, I went to my Dr. and told her that I was going to get a tattoo. She okayed it as long as it was only done in 1 hr increments, and as long as I took my medicine right before the tattoo. She also wrote a note that I gave to the artist that gave her "permission" or whatever. They were very good at timing to make sure that it didn't go over an hour. So, even though I had to sit through a couple of sessions, it was worth it! Also, my artist said that I was bleeding less than most people, so my medicine must have kicked in. That was just my experience, so here is what I would do if I were you... 1. First and foremost, go to your blood Dr. and tell them your plan to get a tattoo. They will either give you a yay or nay. 2. Once you have confirmation that this will be okay medically, make sure that your chosen artist is okay with whatever process that you have to do to get this done. 3. Be prepared that the shop will probably have you sign an addition waiver because of your condition. 4. Also be prepared that your body will not react well and that you could have a partially done tattoo that they can't finish. Good luck!

Question: What is the age of onset for hemophilia? When does hemophilia arise in a person? I know ther are two types and happen every 1 in 5000 and 30000 births but does it arise at birth, or during the younger years?

Answer: Since hemophilia is a genetic disease, you are born with it. Therefore, you should begin to see the effects of it (difficult to stop bleeding, bleeding into joints, et cetera) at a very young age.

Question: How close are scientists to finding a cure to hemophilia? My son has hemophilia and the docs say he will have a cure in his lifetime, but I want to know how close they really are. He is currently taking 2000 iu/kg daily. Im asking because most info you run into is seriously outdated.

Answer: Hemophilia can only be cure if and only if he gets a stem cell implant. So far there is a Japanese scientist that was able to turn an ordinary cell into an immortal stem cell that can generate itself into any tissue/organ that needs to be either replaced or repaired. I would say if the scientific and worldwide bioethics committee would agree for human test subjects right now, the cure would be around by 10 years. But hemophilia is a manageable disease. Just make sure he gets plasma factors in his system every 3 months or so.