Glucose 6 Phosphate Dehydrogenase Deficiency

Question: What are the causes and effects of Glucose-6-Phosphate Dehydrogenase Deficiency?

Answer: Glucose-6-phosphatase dehydrogenase (G-6-PD) deficiency is the most common disease-producing enzymopathy in humans. Inherited as an X-linked disorder, G-6-PD deficiency affects 400 million people worldwide. The disease is highly polymorphic, with more than 300 reported variants. It confers protection against malaria, which probably accounts for its high gene frequency. The G6PD enzyme catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconate while concomitantly reducing the oxidized form of nicotinamide adenine dinucleotide phosphate (NADP+) to nicotinamide adenine dinucleotide phosphate (NADPH). NADPH, a required cofactor in many biosynthetic reactions, maintains glutathione in its reduced form. Reduced glutathione acts as a scavenger for dangerous oxidative metabolites in the cell. With the help of the enzyme glutathione peroxidase, reduced glutathione also converts harmful hydrogen peroxide to water. Red blood cells rely heavily upon G-6-PD activity because it is the only source of NADPH that protects the cells against oxidative stresses; therefore, people deficient in G-6-PD are not prescribed oxidative drugs because their red blood cells undergo rapid hemolysis under this stress. The five classes of G-6-PD deficiency include low, normal, or increased levels of the enzyme. Frequency: Internationally: The highest prevalence rates (with gene frequencies from 5-25%) are found in tropical Africa, the Middle East, tropical and subtropical Asia, some areas of the Mediterranean, and Papua New Guinea. Mortality/Morbidity: The most common clinical feature is a lack of symptoms. Symptomatic patients present with neonatal jaundice and acute hemolytic anemia. Neonatal jaundice: Jaundice usually appears by age 1-4 days, at the same time as or slightly earlier than so-called physiological jaundice and later than in-blood group alloimmunization. Kernicterus is a rare complication. Acute hemolytic anemia: Clinical expression results from stress factors such as oxidative drugs or chemicals, infection, or ingestion of fava beans. Race: G-6-PD deficiency affects all races. The highest prevalence is among persons of African, Asian, or Mediterranean descent. Severity varies significantly between racial groups because of different variants of the enzyme. Severe deficiency variants primarily occur in the Mediterranean population. The enzymatic variants in the African population have more activity and produce a milder form of the disease. Sex: G-6-PD deficiency is an X-linked inherited disease that primarily affects men. Homozygous women are found in populations in which the frequency of G-6-PD deficiency is quite high. Heterozygous (carrier) women can develop hemolytic attacks.

Question: to whom should i consult for my niece's glucose 6 phosphate dehydrogenase deficiency? she was diagnosed thru newborn screening program

Answer: her doctor

Question: HELP! Glucose-6-phosphate dehydrogenase! 10 points to the person with the most answers and are correct? Pleas help. I am trying to finish the project and I am having a little difficulty finding the answsers to these questions. Any answers will be accepted!! 10 points to the person with the most answers and are correct. 1. Classification of GP6D nas a sugar, protein, or fat. 2. Basic information on the structure of the GP6D enzyme 3. Identification of the substrate of GP6D 4. Information on the location of GP6D synthesis within the cell. 5. Explanation of the possible effects of GP6D deficiency on the cellular respiration. 6. Explanation of the possible effects of GP6D deficiency on carbohydrate homeostais 7. Explanation of the possible effects of GP6D on the functioning of at least 2 organelles. THANKS SO MUCH FOR ALL THE HELP!!!!!! Thanks so much for your answer and I apologize that this was listed as a diabetes question. That was a mistake.

Answer: I think it would have been more instructive to Google this: http://en.wikipedia.org/wiki/Glucose-6-p… http://www.nlm.nih.gov/medlineplus/ency/… http://www.emedicine.com/Med/topic900.ht… http://www.rarediseases.org/search/rdbde… http://ghr.nlm.nih.gov/condition=glucose… http://kidshealth.org/parent/general/ach… FYI, very few people with the level of expertise to adequately answer your question have the time or desire to hang out in Answers. I hang out here to read interesting questions (like this one), research them, and answer as best as I can in hopes that I can learn more about diabetes. I'm not sure what this has to do with diabetes, though.

Question: does anyone knows how to prevent or heal my son's G6pd? my son was diagnosed having g6pd (glucose 6 phosphate dehydrogenase deficiency)eversince he was born..is there any possible way for my son to be healed or even recover from it?he is now 1 yr 5mos and i think i dont see any signs or symptoms that he's suffering from that deficiency.will that be leukemia afterwards?

Answer: Im afraid that G6pd is an inherited illness - it occurs almost always in boys. Therefore, it can not be cured and there are no formal treatments as such but there are many things you can do to help your son and reduce the severity of problems that can arise. This condition affects the blood - it is complicated and beyond the scope of your actual question. The condition can cause a Hemolytic (blood) crises of varing degrees - extreme (and thankfully rare) reactions can be fatal. These crises can be triggered by certain drugs and foods. Your doctor will know what drugs to avoid and it is vital that if your son is treated by another doctor they are made aware of his condition - I would strongly advise he wears a 'medic-alert' bracelet. There are some foods that should be avoided - the most important one is Broad Beans. Diseases can trigger hemolytic crises and shouls be avoided. Your son shouls receive all his childhood vaccinations including MMR. He should also be vaccinated against Flu, Hapatitis A and C. Folic Acid supplementation has been proven to help, discuss this with your doctor and perhaps get your son on Folic Acid tablets. In later life, removal of the spleen will help management of the condition. Your son, starting in his teen years, must focus on keeping physically fit and healthy with lots of exercise and a good diet - diabetes can have severe consequences in these patients. Hope this helps.

Question: is there a cure for G6PD affected children? Glucose-6-Phosphate Dehydrogenase(G6PD) deficiency is the most common human enzyme deficiency; an estimated 400 million people worldwide are affected by this enzymopathy. Is there a cure for this deficiency? And are there a research made to find a cure for this problem?

Answer: G6PD is a genetic condition, and would probably require gene therapy for a genuine "cure."

Question: Does anyone know any books with G6PD? Its Glucose-6-Phosphate Dehydrogenase Deficiency. I need one more book on it for a report, but I can't find any. It doesn't have to have much about it. One sentence where it mentions it is good enough. Thanks.

Answer: Any book on medical biochemistry . You will find loads of them on internet sites like gigapedia.com . Specifically you need to look under Carbohydrate Metabolism .

Question: NURSES out there please help? I am student nurse and i have a question How can there be a risk for injury nursing diagnosis when there is a G6PD (glucose 6 phosphate dehydrogenase deficiency) deficiency? Or what are the possible nursing diagnosis for G6PD clients? Please help =)

Answer: im not exactly sure what you are talking about since i am not an RN yet, but i stumbled across this website this morning.. maybe it will help you? http://www.beaumonthospitals.com/pls/por…

Question: I really want to know if this would be true help me ? Glucose-6-phosphate dehydrogenase deficiency? Say theres a man and a woman .. and the man has the disorder and they are going to have kids and if its a girl its going to be a carrier would there be more chance of her having a miscarriage if her body finds that there is something wrong with the child or that the child carries the disorder seeing as a miscarriage is where its getting rid of something that "isnt right" basically

Answer: Her body may cause her to miscarry. If I were you I would talk to a OBGYN.

Question: Genetics question! Please help!!!? Please help with explaining this one: The X-linked allele for glucose 6-phosphate dehydrogenase deficiency (Gd-) also confers resistance to malaria. You make a microscopic examination of the blood of a woman suffering from malaria. You observe that about one-half of the cells contain parasites, whereas one-half of the cells are unaffected. How would you explain this?!? Thank you!!!

Answer: Her father DIDN'T have malaria, and was not even a carrier of that disease.

Question: Can I take Stemulite with a medical condition? Hi I am a GGPD full-defect patient and was wondering if I can take the natural supplement Stemulite (https://secure.truehealthyproducts.com/stemulite.com/index.php?affiliate=783) G6PD deficiency is the lack of glucose-6-phosphate dehydrogenase (an enzyme present in red blood cells) in the blood, which can cause a type of anemia known as hemolytic anemia. Red blood cells carry oxygen in the body and G6PD protects these cells from natural oxygen chemicals that may build up when you have a fever or take certain medications. If there are too many of these chemicals, they can destroy the red blood cells, causing hemolytic anemia. G6PD deficiency is inherited - people are born with the deficiency. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency G6PD deficiency reduces energy available to maintain the integrity of the red cell membrane, which shortens RBC survival. Hemolysis occurs commonly after fever, acute viral and bacterial infections, and diabetic acidosis. Less commonly, hemolysis occurs after exposure to drugs or to other substances that produce peroxide and cause oxidation of Hb and RBC membranes. These drugs and substances include primaquine, salicylates, sulfonamides, nitrofurans, phenacetin, naphthalene, some vitamin K derivatives, dapsone ,phenazopyridine, nalidixic acid, methylene blue ,and, in some whites, fava beans. Whether continued use of the offending drug leads to a compensated hemolytic state or lethal hemolysis depends on the degree of G6PD deficiency and the oxidant potential of the drug. It is G6PD, thanks!

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