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Anemia Of Chronic Disease

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Question: Why do ferritin increase in anemia of chronic disease? Thanks alot...very clear explanation!!

Answer: In anemia of chronic disease without iron deficiency, ferritin levels are normal or high, reflecting the fact that iron is stored within cells, and ferritin is being produced as an acute phase reactant but the cells are not releasing their iron. Iron is not utilized because there is less erythropoiesis (formation of red blood cells & hemoglobin). Thus to store the unused iron, ferritin protein that binds this iron is produced in increased amount. I hope I could make it clear. Good luck!

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