Amyloidosis Immunoglobulin

Question: I need to verify what is primary amyloidosis. http://www.iupui.edu/~amyloid/primary.htm?... is this true: Primary amyloidosis is a disease caused by the abnormal accumulation of protein molecules in body tissues. These proteins are fragments of immunoglobulin (antibody) molecules which are normally present in the blood to give protection against bacteria and other infectious agents. Normally, antibody molecules are constantly being synthesized by cells of the immune system and then, after a finite life span, degraded so that there is a balance between production and degradation In this way our active immune system protects our bodies from a constantly changing array of infectious bacteria and viruses. In primary amyloidosis a defect occurs in the immune system. Excessive amounts of certain antibody molecules are produced and fragments of these molecules get deposited in tissues. These tissue deposits, as they enlarge, damage normal tissues and cause the disease that we know as primary amyloidosis. The information is from Indiana University School of Medicine Can this medical school be trusted with providing correct information? Hey Anj, can wekipedia even be trusted, becuase it can be written by any one and its always changing.

Answer: That's more or less correct. In short primary amylodosis is a metabolic defect which results in abnormal proteins depositing in the various tissues of the body, ie heart, kidneys, brain etc etc. There are several kinds of amyloidosis, nearly all of them with similar outcome. Wikipedia have a more lucid explanation. Wish you the very best