ask our doctors

Cholelithiasis

Get the facts on Cholelithiasis treatment, diagnosis, staging, causes, types, symptoms. Information and current news about clinical trials and trial-related data, Cholelithiasis prevention, screening, research, statistics and other Cholelithiasis related topics. We answer all your qestions about Cholelithiasis.

Question: is there a link between cholelithiasis and vitamin b12 deficiency? Just wondering if there is a link between cholelithiasis (gallbladder disease) and vitamin B12 deficiency? I had my gallbladder out almost 12 months ago and have now found out i am deficient in b12. Just wondering if there is a link! If there is a link do they do some kind of test to confirm or do they just assume? My gp has referred me to a gastroenterologist and I am just curious about how things might go

Answer: B12 is also important in maintaining the nervous system. Nerves are surrounded by an insulating fatty sheath comprised of a complex protein called myelin. B12 plays a vital role in the metabolism of fatty acids essential for the maintainence of myelin. Prolonged B12 deficiency can lead to nerve degeneration and irreversible neurological damage. When deficiency occurs, it is more commonly linked to a failure to effectively absorb B12 from the intestine rather than a dietary deficiency. Absorption of B12 requires the secretion from the cells lining the stomach of a glycoprotein, known as intrinsic factor. The B12-intrinsic factor complex is then absorbed in the ileum (part of the small intestine) in the presence of calcium. Certain people are unable to produce intrinsic factor and the subsequent pernicious anaemia is treated with injections of B12. Vitamin B12 can be stored in small amounts by the body. Total body store is 2-5mg in adults. Around 80% of this is stored in the liver. Vitamin B12 is excreted in the bile and is effectively reabsorbed. This is known as enterohepatic circulation. The amount of B12 excreted in the bile can vary from 1 to 10ug (micrograms) a day. People on diets low in B12, including vegans and some vegetarians, may be obtaining more B12 from reabsorption than from dietary sources. Reabsorption is the reason it can take over 20 years for deficiency disease to develop in people changing to diets absent in B12. In comparison, if B12 deficiency is due to a failure in absorption it can take only 3 years for deficiency disease to occur.


Cholelithiasis News